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Medicinal Chemistry 1 B Pharm 4th Semester Notes PDF [2024]

Hello Dear Friends, How are you all, hope you are doing well, today in this article we are going to tell you how you can download Medicinal Chemistry 1 B.Pharma 4th Semester Notes Download Free PDFs for free. Friends, you will also get to see PDF and download links of B.Pharmacy 4th Semester Handwritten and Standard Notes in this article.

According to the syllabus of 2024 by PCI (Pharmacy Council of India), you will get the link to download all the handwritten and standard notes, you get the option to download all the notes semester wise or unit wise.

Medicinal Chemistry 1 B.Pharm 4th Semester Information:

Course NameB.Pharma
Semester Year4th Semester
Notes TypesHandwritten & Standard Notes
PCI Syllabus NotesLatest PCI 2024
Subject NameMedicinal Chemistry 1
CategoryB Pharm
Telegram Group LinkJoin Us
Official Website PCIwww.pci.nic.in

Note:- Friends, on this website all types of information like – B.Pharma and D.Pharma All Subject PDF Free Notes, Semester Wise Note, Latest Syllabus 2024 and Exam Pattern 2024 Download, Previous Year Question Paper PDF Download etc.

Also Read : B Pharm 1st Semester Notes Free PDFs Download

B Pharm 4th Semester Subject Name 2024

  • Medicinal Chemistry 1
  • Pharmaceutical Organic Chemistry 3
  • Physical Pharmaceutics 2
  • Pharmacology 1
  • Pharmacognosy and Phytochemistry 1

Pharmaceutical Organic Chemistry 2 Syllabus 2024 Pdf Download

Let us see what is in the syllabus of Medicinal Chemistry 1.

B.Pharma Syllabus 2024Download Link
B.Pharma 4th Semester Syllabus PDFCLICK HERE

Unit I

  • A brief introduction Medicinal Chemistry
  • Physicochemical properties of the biological actions
  • History & development of medicinal chemistry
  • Ionization Solubility partition coefficient, hydrogen bonding Chelation, protein binding, Optical & Geometrical isomerism
  • The principles of drug metabolism phase I & Phase II
  • Drug metabolism is affected by stereochemical aspects

Unit 2

Drugs that affect the Autonomic Nervous system.

  • Neurotransmitters Biosynthesis & breakdown of catecholamine. Adrenergic receptors & their distribution.
  • Sympathomimetic agents- Sympathomimetic agents with direct action Nor-epinephrine Epinephrine, Phenylephrine, Dopamine, Methyldopa, Clonidine, Dobutamine Isoproterenol Terbutaline, & Salbutamol. Bitolterol Naphazoline Oxymetazoline & Xylometazoline. Indirectly active agents are Hydroxyamphetamine, Pseudoephedrine, and Propylhexedrine. Agents with a mixed mechanism Ephedrine, Metaraminol.

Adrenergic Antagonists:

  • Alpha-adrenergic blockers- Tolazoline, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide. Blockers of
  • beta-adrenergic receptors- SAR beta-blockers Propranolol, Metibranolol, Atenolol, Betaxolol, Bisoprolol, Esmolol, Metoprolol, Labetalol, Carvedilol.

Unit 3

  • Neurotransmitters of the Cholinergic family: biosynthesis & catabolism of Acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) & their distribution.
  • Parasympathomimetic agents: SAR Parasympathomimetic Agents
  • Direct-acting Agents: Acetylcholine, Carbachol, Bethanechol, Methacholine, Pilocarpine.
  • Indirect-acting inhibitors of Cholinesterase (Reversible & irreversible): Physostigmine, Neostigmine, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride Isofluorphate, Echothiophate iodide, Parathion, & Malathion.
  • Cholinesterase reactivator: Pralidoxime chloride.

Cholinergic Blocking Agent:

  • SAR of cholinolytic substances Alkaloids with a solanaceous structure & analogs: Atropine sulfate, Hyoscyamine sulfate Scopolamine hydrobromide Homatropine hydrobromide Ipratropium bromide. 
  • Synthetic cholinergic blocking agents: Tropicamide, Cyclopentolate hydrochloride, Clidinium bromide Dicyclomine hydrochloride Glycopyrrolate, Methantheline bromide, Propantheline bromide Benztropine mesylate Orphenadrine citrate Biperidine hydrochloride Procyclidine hydrochloride Tridihexethyl chloride Isopropamide iodide Ethopropazine hydrochloride.

Unit 4

Drugs that act upon Central Nervous System:

  • Sedatives & Hypnotics: Benzodiazepines, SARs of Benzodiazepines, Chlordiazepoxide, Diazepam, Oxazepam, Chlorazepate, Lorazepam, Zolpidem, Alprazolam. Barbiturates, SAR of barbiturates Phenobarbital, Barbital, Mephobarbital, & Amobarbital. Butabarbital & Pentobarbital. Secobarbital Other: Imides & imides Glutethmide. Alcohol & its carbamate derivatives Meprobomate, Ethchlorvynol. Aldehyde & its derivatives Triclofos sodium Paraldehyde.
  • Antipsychotics Phenothiazines: SAR of Phenothiazeines Promazine hydrochloride & Chlorpromazine hydrochloride, Triflupromazine, Thioridazine hydrochloride, Piperacetazine hydrochloride, Prochlorperazine maleate, Trifluoperazine hydrochloride. Ring Analogues to Phenothiazeines: Chlorprothixene, Thiothixene, Loxapine succinate, Clozapine. Fluro butyrophenones: Haloperidol, Droperidol, Risperidone. Beta amino ketones Molindone hydrochloride. Benzamides: Sulpieride. 
  • Anticonvulsants SAR of Anticonvulsants mechanism of action of anticonvulsants Barbiturates Phenobarbitone, Metha barbital. Hydantoins Phenytoin, Mephenytoin, Etherton Oxazolidine dines: Trimethadione, Paramethadione Succinimides: Phasianidae, Ethosuximide, Ethosuximide Urea, & monocultures Phenacemide, Carbamazepine Benzodiazepines: Clonazepam Other: Primidone, Valproic acid, Gabapentin, Felbamate.

Unit 5

Drugs that act on the Central Nervous System:

  • General anesthetics: Inhalation anesthetics Halothane, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane. Barbiturates that have ultra-short-acting properties: Methohexital sodium, Thiamylal sodium, and Thiopental sodium. Dissociative anesthetics Ketamine hydrochloride. Analgesics for non-narcotic & narcotic use. Morphine & related drugs SARs of Morphine analogs, Morphine sulfate, Codeine, Meperidine hydrochloride, Anilerdine hydrochloride Diphenoxylate hydrochloride Loperamide hydrochloride Fentanyl citrate Methadone hydrochloride Propoxyphene hydrochloride Pentazocine Levorphanol tartrate.
  • Narcotic antagonists: Nalorphine hydrochloride, Levallorphan tartrate, Naloxone hydrochloride. Agents to reduce inflammation: Sodium salicylate, Aspirin, Mefenamic acid, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone.

Download free Pdf of notes of Medicinal Chemistry 1

You can download free Pdfs of Medicinal Chemistry 1 Standard Notes by clicking on the download links given below table.

Standard NotesDownload Link
UNIT-1CLICK HERE
UNIT-2CLICK HERE
UNIT-3CLICK HERE
UNIT-4CLICK HERE
UNIT-5CLICK HERE

You can download free Pdfs of Medicinal Chemistry 1 Handwritten Notes by clicking on the download links given below table.

Handwritten NotesDownload Link
UNIT-1CLICK HERE
UNIT-2CLICK HERE
UNIT-3CLICK HERE
UNIT-4CLICK HERE
UNIT-5CLICK HERE

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